Cryptococcal meningoencephalitis relapse after an eight-year delay: an interplay of infection and immune reconstitution
We report a case of a symptomatic relapse of HIV-related cryptococcal meningoencephalitis eight years after the first diagnosis on the background of immune reconstitution. The findings as well as the clinical course suggests a combination of smouldering localised infection and enhanced inflammatory reaction related to immune restoration due to antiretroviral therapy. A combination of antifungal and anti-inflammatory therapy resulted in clinical and radiological improvement. Our case challenges the concept that immune reconstitution inflammatory syndrome and microbiological relapse are dichotomous entities.
Source: International Journal of STD and AIDS - Category: Global & Universal Authors: Katchanov, J., Blechschmidt, C., Nielsen, K., Branding, G., Arasteh, K., Tintelnot, K., Meintjes, G., Boulware, D. R., Stocker, H. Tags: Case reports Source Type: research