Retinoblastoma: An update

Retinoblastoma is the most common ocular malignancy in children, and is initiated by mutation of the RB1 gene. The tumor may be unilateral or bilateral and can be inherited. Overall survival, eye salvage, and preservation of vision are largely dependent on the stage of disease at presentation. Despite a recently-enhanced understanding of the etiology of retinoblastoma, the mortality associated with it remains high worldwide. This may relate to a continuing lack of awareness of the lesion by laypersons, and unavailability of modern treatment facilities.

Source: Seminars in Diagnostic Pathology - October 16, 2015 Category: Pathology Authors: Kushal S. Delhiwala, V.P. Indu, Kaustubh Mulay, Vikas Khetan Source Type: research