Diagnostic pathology issue about neuroendocrine Neoplasms of the lung

Neuroendocrine neoplasms are a complex group of neoplasms that arise in the lung and other organs and challenge practicing pathologists with a variety of diagnostic problems. The origin of these neoplasms has been somewhat controversial. Pulmonary carcinoid tumors are thought to be derived from neuroendocrine cells distributed throughout the airways epithelium while small cell carcinoma and large cell neuroendocrine carcinoma, high-grade neoplasms that exhibit similar neuroendocrine phenotype as carcinoid tumors appear to have an origin more akin to carcinomas of the lung.
Source: Seminars in Diagnostic Pathology - Category: Pathology Authors: Source Type: research