Metformin affects the characteristics of HepG2 cells by regulating macrophage polarization in a co-culture microenvironment.

CONCLUSIONS: Metformin can skew RAW264.7 macrophages toward different phenotypes according to changes in the microenvironment, which may affect the inflammatory conditions mediated by macrophages, induce apoptosis, and inhibit the proliferation and migration of HepG2 cells. Notch signaling pathway is a potentially important mechanism in the regulation of metformin on macrophage polarization and the subsequent change of hepatoma cells. This article is protected by copyright. All rights reserved. PMID: 26467463 [PubMed - as supplied by publisher]
Source: Diabetes Metab - Category: Endocrinology Authors: Tags: Diabetes Metab Res Rev Source Type: research