Multipotent luminal mammary cancer stem cells model tumor heterogeneity

Conclusions: Since the majority of human tumors are of the luminal subtype, understanding the cell of origin of these tumors and how they relate to other tumor subtypes will impact cancer therapy. Analysis of clonal cell lines derived from different tumor subtypes suggests a developmental hierarchy of MaCSCs, which may provide insights into the progression of human breast cancer.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research