Transient, activity dependent inhibition of transmitter release from low threshold afferents mediated by GABA A receptors in spinal cord lamina III/IV

Conclusions:
These observations suggest that afferent driven release of GABA onto low threshold afferent terminals is most effective following the first action potential in a train and serves to suppress the initial strong excitatory drive onto dorsal horn circuitry.

Source: Molecular Pain - October 13, 2015 Category: Molecular Biology Authors: Chiara BetelliAmy MacDermottRita Bardoni Source Type: research