expression is inversely correlated with amplification or expression and associated with poor survival in non--amplified neuroblastoma

Neuroblastoma (NB) is the most common extra cranial solid tumor in childhood and the most frequently diagnosed neoplasm during infancy. A striking feature of this tumor is its clinical heterogeneity. Several tumor progression markers have been delineated so far, among which MYCN amplification, which occurs in about 25% of total NB cases, with the percentage increasing to 30% in advanced stage NB. Although MYCN amplification is strongly correlated with NB of poor outcome, the MYCN status cannot alone predict all cases of poor survival in NB.

Source: Molecular Oncology - October 7, 2015 Category: Cancer & Oncology Authors: Caroline Masserot, Qing-Yuan Liu, Eric Nguyen, Charles-Henry Gattolliat, Dominique Valteau-Couanet, Jean Bénard, Catherine Huber, Evelyne Ségal-Bendirdjian Source Type: research