The Perilipin 2 (PLIN2) gene Ser251Pro missense mutation is associated with reduced insulin secretion and increased insulin sensitivity in Italian obese subjects.

CONCLUSION: We observed a strong significant association between the PLIN2 Pro251 mutation and lower insulin secretion associated with an increased insulin-sensitivity. This article is protected by copyright. All rights reserved. PMID: 26443937 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26443937?dopt=Abstract

Source: Diabetes Metab - October 7, 2015 Category: Endocrinology Authors: Sentinelli F, Capoccia D, Incani M, Bertoccini L, Severino A, Pani MG, Manconi E, Cossu E, Leonetti F, Baroni MG Tags: Diabetes Metab Res Rev Source Type: research