Ophthalmic immunoglobulin G4 – related orbital disease (IGG4-Rd): Current CONCEPTS

IgG4-related disease (IgG4-RD) is a distinct entity which frequently occurs in an ophthalmic location. As such, IgG4-RD is not limited to the orbit but may also involve other anatomical structures in and around the eye. Hence, the term “ophthalmic IgG4-RD” is preferred over “orbital IgG4-RD.” A high level of suspicion for the diagnosis can be derived from careful clinicoradiologic examination; the use of immunohistochemical staining for IgG4 in the context of characteristic histopathologic features is needed to reach a correct diagnosis.

Source: Seminars in Diagnostic Pathology - October 6, 2015 Category: Pathology Authors: Kaustubh Mulay Source Type: research