Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness

In this study, CNV analysis of DISC1 and its binding partners PAFAH1B1, NDE1, NDEL1, FEZ1, MAP1A, CIT and PDE4B in Scottish and Northern Swedish population-based samples was carried out using multiplex amplicon quantification. Here, we report the finding of rare CNVs in DISC1, NDE1 (together with adjacent genes within the 16p13.11 duplication), NDEL1 (including the overlapping MYH10 gene) and CIT. Our findings provide further evidence for involvement of DISC1 and its interaction partners in neuropsychiatric disorders and also for a role of structural variants in the aetiology of these devastating diseases.Mol Neuropsychiatry 2015;1:175-190

http://www.karger.com/Article/FullText/438788

Source: Molecular Neuropsychiatry - October 6, 2015 Category: Neuroscience Source Type: research