Abstract CN10-01: Tumor surveillance strategies in pediatric hereditary cancer predisposition syndromes

Cancer is the most common cause of disease-related death in children beyond the neonatal period. Primary prevention has not been commonly considered in the management of childhood cancers as ‘environmental’ agents have not generally been associated with cancer risk. Evidence from genetic and genomic studies supports a rapidly increasing role for inherited or de novo genetic alterations in the etiology of many childhood cancers. Diverse phenotypes have been associated with many of these gene alterations, and genotype:phenotype correlations continue to be defined. Some cancer predisposition syndromes are associated with other non-neoplastic congenital or developmental anomalies, whereas other syndromes appear to be limited to occurrence of a few or many possible cancer types. In the past, the role of genetic testing of children was questioned based on the lack of evidence for effective intervention or improved outcomes. However, the creation and implementation of several comprehensive multi-modality surveillance protocols has offered means by which children at genetic risk of cancer may benefit from early tumor detection and treatment to reduce morbidity and mortality. Emerging discussion of potential opportunities for targeted chemoprevention have also begun. This talk will highlight some of these scenarios, present algorithms whereby such approaches can be used, and explore the complex medical, psychosocial, ethical and financial challenges and opportunities where...
Source: Cancer Prevention Research - Category: Cancer & Oncology Authors: Tags: Pediatric Malignancies: Oral Presentations - Invited Abstracts Source Type: research