Activation of peripheral KCNQ channels attenuates inflammatory pain

Conclusions: Our findings suggest that the peripheral sensory neuron is the main target for KCNQ channel openers to induce analgesia. Therefore, peripheral KCNQ channel openers that do not penetrate the CNS may be suitable analgesic drugs as they would prevent CNS side effects.

http://www.molecularpain.com/content/10/1/15

Source: Molecular Pain - February 21, 2014 Category: Molecular Biology Authors: Hiroki HayashiMasashi IwataNoboru TsuchimoriTatsumi Matsumoto Source Type: research