Chk1 phosphorylated at serine is a predictor of early local recurrence and radio-resistance in breast cancer

Radiation-induced DNA damage activates the DNA damage response (DDR). DDR up-regulation may predict radio-resistance and increase the risk of early local recurrence despite radiotherapy in early stage breast cancers. In 1755 early stage breast cancers, DDR signalling [ATM, ATR, total Ckh1, Chk1 phosphorylated at serine 345 (pChk1), Chk2, p53], base excision repair [PARP1, POLβ, XRCC1, FEN1, SMUG1], non-homologous end joining (Ku70/Ku80, DNA-PKcs) and homologous recombination [RAD51, BRCA1, γH2AX, BLM, WRN, RECQL5, PTEN] protein expression was correlated to time to early local recurrence.

Source: Molecular Oncology - October 2, 2015 Category: Cancer & Oncology Authors: Nouf Alsubhi, Fiona Middleton, Tarek MA. Abdel-Fatah, Peter Stephens, Rachel Doherty, Arvind Arora, Paul M. Moseley, Stephen YT. Chan, Mohammed A. Aleskandarany, Andrew R. Green, Emad A. Rakha, Ian O. Ellis, Stewart G. Martin, Nicola J. Curtin, Srinivasan Source Type: research