DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis

This study demonstrates for the first time a non-linear dose–response for alkylation-induced colorectal carcinogenesis and reveals DNA repair by MGMT, but not AAG, as a key node in determining a carcinogenic threshold.

Source: Carcinogenesis - September 30, 2015 Category: Cancer & Oncology Authors: Fahrer, J., Frisch, J., Nagel, G., Kraus, A., Dorsam, B., Thomas, A. D., Reissig, S., Waisman, A., Kaina, B. Tags: Original Manuscript Source Type: research