Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men.

CONCLUSIONS: The combination of lower dietary FA oxidation and a prolonged increase in DNL observed in men may represent partitioning of FA into esterification and storage pathways within the liver leading to greater VLDL-TG production and predispose to the sex difference in hepatic steatosis.
PMID: 26414963 [PubMed - as supplied by publisher]

Source: Diabetes Metab - September 28, 2015 Category: Endocrinology Authors: Pramfalk C, Pavlides M, Banerjee R, McNeil CA, Neubauer S, Karpe F, Hodson L Tags: J Clin Endocrinol Metab Source Type: research