5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin

5-Hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown. As Wnt/β-catenin signalling is highly dysregulated in a majority of HCC, this study explored the regulation of Wnt/β-catenin signalling by 5-HT. The expression of various 5-HT receptors was studied by quantitative real-time polymerase chain reaction (qPCR) in HCC cell lines as well as in 33 pairs of HCC tumour and corresponding adjacent non-tumour tissues.

Source: Molecular Oncology - September 29, 2015 Category: Cancer & Oncology Authors: Sarwat Fatima, Xiaoki Shi, Zesi Lin, Guo-qing Chen, Xiao-hua Pan, Justin Che–Yuen Wu, John W. Ho, Nikki P. Lee, Hengjun Gao, Ge Zhang, Aiping Lu, Zhao Xiang Bian Source Type: research