Pedunculopontine arousal system physiology – Deep brain stimulation (DBS)

Publication date: Available online 25 September 2015 Source:Sleep Science Author(s): Edgar Garcia-Rill, Brennon Luster, Stasia D’Onofrio, Susan Mahaffey, Veronica Bisagno, Francisco J. Urbano This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.
Source: Sleep Science - Category: Sleep Medicine Source Type: research