Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons

Conclusion:
INaRs are associated with inherited and acquired pain disorders. However, our ability to selectively target and study this current has been hindered due to limited understanding of how it is generated in sensory neurons. This study identified Navβ4 as an important regulator of INaR and excitability in sensory neurons. As such, Navβ4 is a potential target for the manipulation of pain sensations.

Source: Molecular Pain - September 25, 2015 Category: Molecular Biology Authors: Cindy BarbosaZhi-Yong TanRuizhong WangWenrui XieJudith StrongReesha PatelMichael VaskoJun-Ming ZhangTheodore Cummins Source Type: research