Regulation and localization of vascular endothelial growth factor within the mammary glands during the transition from late gestation to lactation

The vascular network within the developing mammary gland (MG) grows in concert with the epithelium to prepare for lactation, although the mechanisms coordinating this vascular development are unresolved. Vascular endothelial growth factor A (VEGF-A) mediates angiogenesis and vascular permeability in the MG during pregnancy and lactation, where its expression is upregulated by prolactin. Given our previous finding that late-gestational hyperprolactinemia induced by domperidone (DOM) increased subsequent milk yield from gilts, we sought to establish changes in vascular development during late gestation and lactation in the mammary glands of these pigs as well as determine whether DOM altered MG angiogenesis and the factors regulating it.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research