Donepezil-associated Manic Episode with Psychotic Features: A Case Report and Review of the Literature
: Reports of manic episodes associated with the use of cholinesterase inhibitors (including donepezil) are limited. Despite the previous notion of pro-cholinergic drugs potentially inducing depression, the contemporary evidence for cholinesterase inhibitors appears to also indicate a trend for elevated mood (in patients with or without a history of depressive disorder).
Source: General Hospital Psychiatry - Category: Psychiatry Authors: Ana Hategan, James A. Bourgeois Source Type: research