Randomized Trial of Bicarbonate or Saline Study for the Prevention of Contrast-Induced Nephropathy in Patients with CKD

Sodium bicarbonate vs sodium chloride has always plagued those of us trying to prevent acute contrast nephropathy.  This prospective, double-blind, multicenter randomized clinical trial of 391 with eGFR < 45 ml/min were randomized to either infusion.  There was no difference in the primary composite outcome of mortality, dialysis, or a sustained 20% reduction in eGFR at 6 months between the two groups.  Furthermore, there was also no difference in the incidence of acute contrast nephropathy between the treatment groups (14.5% versus 12.1%, respectively; P=0.20). : Acetylcysteine for Prevention of Renal Outcomes in Patients Undergoing Coronary and Peripheral Vascular Angiography: Main Results From the Randomized Acetylcysteine for Contrast-Induced Nephropathy Trial (ACT) ASN 2010 Late Breaking Clinical Trial Results | SHARP, Preclot, more Late Breaking Clinical Trials at ASN 2011 – FISH study and more
Source: Nephrology Now - Category: Urology & Nephrology Authors: Tags: Acute Kidney Injury Clinical Nephrology Contrast Nephropathy Source Type: research