Risk of Adverse Pregnancy Outcomes in Women with CKD

With the increasing prevalence of CKD in pregnancy, it is important that both physicians and patients are aware of the risks.  In this Torino-Cagliari Observational Study (TOCOS), 504 pregnancies in women with CKD were compared with 836 low-risk pregnancies in women without CKD.  There were multiple pregnancy outcomes that were studied and divided into “general” combined outcome (preterm delivery, NICU, SGA); and “severe” combined outcome (early preterm delivery, NICU, SGA).  The risk for adverse outcomes increased across stages (for stage 1 versus stages 4-5: “general” combined outcome, 34.1% versus 90.0%; “severe” combined outcome, 21.4% versus 80.0%; P<0.001). Moreover, stage 1 CKD was also with adverse general combined pregnancy outcome  in women without baseline hypertension, proteinuria, or systemic disease (OR, 1.88; 95% CI, 1.27 to 2.79). The risk of intrauterine death did not differ between patients and controls. : Vitamins C and E to Prevent Complications of Pregnancy-Associated Hypertension Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study Pregnancy Outcomes in Women with Chronic Kidney Disease: A Systematic Review
Source: Nephrology Now - Category: Urology & Nephrology Authors: Tags: Chronic Kidney Disease Pregnancy and Hypertension/Renal Disease Source Type: research