Physiologic Aspects of the Piglet as a Model of Neonatal Hypoxia and Reoxygenation

Every year, there are approximately one million newborns die because of birth asphyxia. For those who survive, they have an increased risk for adverse neurodevelopmental outcomes due to the insult. Newborn piglets are a useful model for hypoxia-ischemic encephalopathy injury in human newborns. We here describe a swine model of neonatal hypoxia and reoxygenation, the instrumentation procedures and hypoxia-reoxygenation protocol. The model allows observation of physiological changes of systemic and regional circulations including the cerebral perfusion, as well as biochemical and histological studies of hypoxia-reoxygenation injury. Further, translational evaluation of therapeutic interventions for hypoxia-ischemic encephalopathy can be conducted.
Source: Springer protocols feed by Neuroscience - Category: Neuroscience Source Type: news