Mitochondrial and bioenergetic dysfunction in trauma-induced painful peripheral neuropathy

Conclusion: Traumatic peripheral nerve injury induces persistent mitochondrial and bioenergetic dysfunction which implies that pharmacological agents which seek to normalize mitochondrial and bioenergetic dysfunction could be expected to be beneficial for pain treatment. Increases in both glycolytic acidification and non-glycolytic acidification suggest that pH sensitive drugs which preferentially act on acidic tissue will have the ability to preferential act on injured nerves without affecting healthy tissues.
Source: Molecular Pain - Category: Molecular Biology Authors: Source Type: research