Implications of obesity for pharmacology and toxicology

3.5 out of 5 stars A Review of the Toxicologic Implications of Obesity. Zuckerman M et al. J Med Toxicol 2015 Sep;11(3):342-54 Abstract The authors of this thought-provoking study propose that obese patients be considered a “special population” — similar to children, the elderly, and pregnant women — for matters of medical toxicology. Obesity — defined as a body mass index (BMI) > 30 kg/m2 — is associated with a number of pharmacokinetic and pharmacodynamic changes that can impact on toxicology: increased blood volume and cardiac output impaired respiratory function alterations in gastric emptying (especially after bariatric surgery) altered volume of distribution These are all important issues, and will become more so in the future as the rate of obesity increased. One group estimated that by the year 2030 obese Americans will constitute over half the population. Unfortunately, since little hard research has been done on this topic, there is little hard data here one can bring to the beside at this point. One important consideration: When dosing lipid rescue therapy, the initial bolus is 1.5 mL/kg lean body weight.
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical medical toxicology obesity pharmacodynamics pharmacokinetics Source Type: news