Perinatal Administration of a Selective Serotonin Reuptake Inhibitor Induces Impairments in Reproductive Function and Follicular Dynamics in Female Rat Offspring

Conclusions:
This is the first study to investigate the postnatal effects of maternal perinatal exposure to FLX on adult offspring reproduction. We show that genes that regulate serotonin signaling and action in the ovary are altered in prenatally FLX-exposed offspring, which when coupled with increased expression of components of the core Circadian Locomotor Output Cycles Kaput (CLOCK) gene regulatory loop may suggest an interaction between serotonergic signaling and clock gene signaling pathways leading to the altered reproductive phenotype.

Source: Reproductive Sciences - September 16, 2015 Category: Reproduction Medicine Authors: Moore, C. J., DeLong, N. E., Chan, K. A., Holloway, A. C., Petrik, J. J., Sloboda, D. M. Tags: Original Articles Source Type: research