Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell

Conclusions:
Adiposity is associated with changes in the expression of genes important in cellular growth, cell cycle progression, and inflammation. The upregulation of the metabolic regulator gene PPM1L suggests that adiposity induces an abnormal metabolic follicular environment, potentially altering folliculogenesis and oocyte quality.

Source: Reproductive Sciences - September 16, 2015 Category: Reproduction Medicine Authors: Merhi, Z., Polotsky, A. J., Bradford, A. P., Buyuk, E., Chosich, J., Phang, T., Jindal, S., Santoro, N. Tags: Original Articles Source Type: research