Everolimus immunosuppression in kidney transplantation: What is the optimal strategy?

Two main everolimus-based strategies have been pursued to facilitate calcineurin inhibitor (CNI) reduction after kidney transplantation: (i) everolimus with reduced CNI exposure from time of transplant (ii) pre-emptive introduction of everolimus with CNI reduction or withdrawal at some point post-transplant. Randomized trials have shown no loss of immunosuppressive efficacy for everolimus (targeting 3–8ng/mL) with reduced-exposure CNI versus standard-exposure CNI and mycophenolic acid (MPA) in low-to-moderate risk patients.

Source: Transplantation Reviews - September 17, 2015 Category: Transplant Surgery Authors: Oliver Witzke, Claudia Sommerer, Wolfgang Arns Source Type: research