Comparative effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus

Patent ductus arteriosus (PDA) is common in extremely premature infants and associated with increased morbidity and mortality. Medical management of PDA uses either indomethacin or ibuprofen. Despite numerous studies, uncertainty exists as to which drug is safer or more effective; we sought to fill this knowledge gap.

Source: Early Human Development - September 16, 2015 Category: Perinatology & Neonatology Authors: Brian C. Gulack, Matthew M. Laughon, Reese H. Clark, Meera N. Sankar, Christoph P. Hornik, P. Brian Smith Source Type: research