OncDRS: An Integrative Clinical and Genomic Data Platform for Enabling Translational Research and Precision Medicine

Publication date: Available online 14 September 2015 Source:Applied & Translational Genomics Author(s): Jomol Mathew, Ameet Pathak, John Orechia, Yunling Shi, Aniket Nawani, Andrey Belozerov, Caitlin Fontes, Camille Lakhiani, Chetan Jawale, Chetansharan Patel, Daniel Quinn, Dmitry Botvinnik, Eddie Mei, Elizabeth Cotter, James Byleckie, Mollie Ullman-Cullere, Padam Chhetri, Poornima Chalasani, Purushotham Karnam, Ronald Beaudoin, Sandeep Sahu, Yelena Belozerova We live in the genomic era of medicine, where a patient’s genomic/molecular data is becoming increasingly important for disease diagnosis, identification of targeted therapy, and risk assessment for adverse reactions. However, decoding the genomic test results and integrating it with clinical data for retrospective studies and cohort identification for prospective clinical trials is still a challenging task. In order to overcome these barriers, we developed an overarching enterprise informatics framework for translational research and personalized medicine called Synergistic Patient and Research Knowledge Systems (SPARKS) and a suite of tools called Oncology Data Retrieval Systems (OncDRS). OncDRS enables seamless data integration, secure and self navigated query and extraction of clinical and genomic data from heterogeneous sources. Within a year of release, the system has facilitated more than 1500 research queries and has released data for more than 50 researc...
Source: Applied and Translational Genomics - Category: Genetics & Stem Cells Source Type: research