Determination of CYP3A4 Inducing Properties of Compounds Using a Laboratory-Developed Cell-Based Assay

In conclusion, the present study demonstrated that this cell-based assay can be used as a tool to evaluate the potential CYP3A4 induction properties of compounds. However, molecular docking data have not provided satisfactory pointers to differentiate between CYP3A4 inducers from noninducers or from inhibitors, more comprehensive molecular screening may be indicated.

Source: International Journal of Toxicology - September 13, 2015 Category: Toxicology Authors: Seah, T. C., Tay, Y. L., Tan, H. K., Tengku Muhammad, T. S., Wahab, H. A., Tan, M. L. Tags: Regular Articles Source Type: research