The Retroviral Cyclin Controls CDK8-mediated Transcription Elongation and Reinitiation

In conclusion, not only does RV-cyclin direct CDK8 to specific genes during tumor development, RV-cyclin enhances CDK8 kinase activity while it is there. The end result of the CDK8-RV-cyclin interaction is a rise in the mRNA levels of another pool of oncogenes, the serum-response genes. This is one mechanism by which RV-cyclin could contribute to the development of walleye dermal sarcoma.
Source: New Horizons in Translational Medicine - Category: Research Source Type: research