Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, it remains a huge challenge to understand the cellular and molecular mechanisms of the aggressive behaviour of EOC cells. Here we investigated the role of an immunomodulatory cytokine IL-33 and its receptor ST2 in mediating the growth and metastasis of EOC. Our data show that both IL-33 and ST2 were highly up-regulated in EOC tumours compared with normal ovary and ovarian benign tumours, and the expression levels were further increased in tumour tissues at the metastatic site.

Source: Molecular Oncology - September 8, 2015 Category: Cancer & Oncology Authors: Xiaoguang Tong, Mark Barbour, Kezuo Hou, Chao Gao, Shuang Cao, Jingli Zheng, Yang Zhao, Rong Mu, Hui-Rong Jiang Source Type: research