Limited changes in spinal lamina I dorsal horn neurons following the cytotoxic ablation of non-peptidergic C-fibers

Conclusions: Our results demonstrate that the deletion of the non-peptidergic afferents, at the L4–L5 spinal levels, is not sufficient to trigger the de novo expression of NK-1r by projection pyramidal neurons but increases the expression of NK-1r in fusiform and multipolar projection neurons. Furthermore, our data suggest that a neuropathic component is essential to trigger the expression of NK-1r by pyramidal neurons.

http://www.molecularpain.com/content/11/1/54

Source: Molecular Pain - September 9, 2015 Category: Molecular Biology Authors: Abeer SaeedSophie PawlowskiAlfredo Ribeiro-da-Silva Source Type: research