Differential Effects of Oxycodone, Hydrocodone, and Morphine on Activation Levels of Signaling Molecules

ConclusionsVarious opioids differentially modulate the baseline activation levels of signaling molecules, which in turn results in ligand‐selective effects on the responses to a D2/D3 dopamine receptor agonist. This demonstrates a complex interplay between opioid receptors and D2DRs, and supports the notion that various opioids carry differential risks to the dopamine reward system. This information should be considered when prescribing opioid pain medication, to balance effectiveness with minimal risk.

Source: Pain Medicine - September 9, 2015 Category: Anesthesiology Authors: Michael A. Emery, M. L. Shawn Bates, Paul J. Wellman, Shoshana Eitan Tags: Brief Research Report Source Type: research