Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects

Immunology and metabolism have always been considered as distinct disciplines. However, recent advances in the understanding of immune functions under normal and disease conditions associate these branches with intricate networks. In this context, most cancer cells predominantly undergo high rate of glycolysis, up to 200 times higher than those of their normal tissues even in the absence of oxygen. Such effect is called “Warburg effect” and results in major changes in inflammation and the immune response [1–3].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Source Type: research