Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury

Conclusion: Our findings showed that LTB4, which may originate from microglia, can activate BLT1 receptors which are expressed on the membrane of spinal dorsal horn neurons during neuropathic pain. This glia-neuron interaction induces the enhancement of NMDA currents through intracellular G-proteins. The enhancement of NMDA receptor sensitivity of dorsal horn neurons may lead to central sensitization, leading to mechanical pain hypersensitivity.

http://www.molecularpain.com/content/11/1/53

Source: Molecular Pain - September 9, 2015 Category: Molecular Biology Authors: Yasukuni KiyoyukiWataru TaniguchiMasamichi OkuboHiroki YamanakaKimiko KobayashiNaoko NishioTerumasa NakatsukaKoichi Noguchi Source Type: research