Inhibition of cellular transdifferentiation by losartan minimizes but does not reverse type 2 diabetes-induced renal fibrosis
Conclusions:
Cellular transition may play a role in diabetes-inducing renal fibrogenesis in both AngII-TGF-β1 axis-dependent and independent manners. Losartan was efficient in preventing cells from undergoing further transdifferentiation, but this strategy was not sufficient to induce regression of the pre-existing tissue fibrosis.
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - Category: Biomedical Science Authors: Arnoni, C. P., Maquigussa, E., Passos, C. S., Pereira, L. G., Boim, M. A. Tags: Original Articles Source Type: research
More News: Biomedical Science | Cozaar | Diabetes | Diabetes Type 2 | Endocrinology | Glomeruli | Hypertension | Insulin | Losartan | Proteinuria | Study