Fatty acid binding protein deletion suppresses inflammatory pain through endocannabinoid/N-acylethanolamine-dependent mechanisms

Conclusions:
This study demonstrates that mice lacking FABPs possess elevated levels of N-acylethanolamines, consistent with the idea that FABPs regulate the endocannabinoid and N-acylethanolamine tone in vivo. The antinociceptive effects observed in the knockout mice support a role for FABPs in regulating nociception and suggest that these proteins should serve as targets for the development of future analgesics.

Source: Molecular Pain - August 28, 2015 Category: Molecular Biology Authors: Martin KaczochaSherrye GlaserThomas MaherBrendan ClavinJohn HamiltonJoseph O¿RourkeMario RebecchiMichelino PuopoloYuji OwadaPanayotis Thanos Source Type: research