Diagnosis and therapy of antiphospholipid syndrome.

Diagnosis and therapy of antiphospholipid syndrome. Pol Arch Med Wewn. 2015 Jul 26; Authors: Pengo V, Denas G, Padayattil J, Zoppellaro G, Bison E, Banzato A, Hoxha A, Ruffatti A Abstract The antiphospholipid syndrome (APS) is a clinical condition still not well defined. Although the clinical component is well established, the laboratory part is a mood issue. According to present guidelines, three test [(Lupus Anticoagulant, anticardiolipin (aCL) and anti β2-glycoprotein I (aβ2GPI) antibodies] are officially recommended to assess the presence of antiphospholipid (aPL) antibodies. According to test positivity, patients are classify into categories in clinical studies. However, it is now clear that classification categories have a different impact on clinical course of APS. Indeed, patients and healthy carriers with a full positive antibody profile (triple positivity) are those at highest risk of events. Patient with a single test positivity are those at lower risk. In this review, on the base of laboratory profile, we grade the diagnosis of APS into definite, probable/possible and uncertain. Three paragraphs are then dedicated to secondary prevention of thrombotic APS, prevention of pregnancy morbidity and treatment of catastrophic APS. Finally, new tools in the laboratory diagnosis and treatment are highlighted. PMID: 26307097 [PubMed - as supplied by publisher]
Source: Polskie Archiwum Medycyny Wewnetrznej - Category: Internal Medicine Tags: Pol Arch Med Wewn Source Type: research