The role of blood rheology in sickle cell disease

Studies performed in the last decades have highlighted the need to better understand the contribution of the endothelium, vascular function, oxidative stress, inflammation, coagulation, hemolysis and vascular adhesion mechanisms to the pathophysiology of acute vaso-occlusive like events and chronic organ damages in sickle cell disease (SCD). Although SCD is a hemorheological disease, a few works focused on the contribution of blood viscosity, plasma viscosity, red blood cell deformability and aggregation in the pathophysiology of SCD.

Source: Blood Reviews - August 25, 2015 Category: Hematology Authors: Philippe Connes, Tamas Alexy, Jon Detterich, Marc Romana, Marie-Dominique Hardy-Dessources, Samir K. Ballas Tags: REVIEW Source Type: research