Does miRNA‐155 Promote Cyclooxygenase‐2 Expression in Cancer?

ABSTRACT MicroRNA (miR)‐155 and cyclooxygenase (COX)‐2 are both elevated in numerous cancers including colorectal cancer. MiR‐155 enhances COX‐2 expression and is an established regulator of epithelial‐mesenchymal transition and inflammation. Inhibition of miR‐155 or COX‐2 exhibit similar negative effects on tumorigenicity. Thus, it is hypothesized that miR‐155 may be a promising target for antagonizing COX‐2 expression in colorectal and other cancers.
Source: Drug Development Research - Category: Drugs & Pharmacology Authors: Tags: Research Commentary Source Type: research