Kidney function changes with aging in adults: comparison between cross‐sectional and longitudinal data analyses in renal function assessment

In conclusion, our findings indicated that one should be cautious in interpreting the renal function decline rate with aging information because its estimation was highly depended on the statistical analyses. From our analyses, a population LT analysis (e.g., random coefficient model) is recommended if individualization is critical, such as a dose adjustment based on the renal function during a chronic therapy. This article is protected by copyright. All rights reserved.

Source: Biopharmaceutics and Drug Disposition - July 1, 2015 Category: Drugs & Pharmacology Authors: Sang M. Chung, David J. Lee, Austin Hand, Philip Young, Jayabharathi Vaidyanathan, Chandrahas Sahajwalla Tags: Original Paper Source Type: research