Microenvironment acidity as a major determinant of tumor chemoresistance: Proton Pump Inhibitors (PPIs) as a novel therapeutic approach

Despite the major progresses in biomedical research and the development of novel therapeutics and treatment strategies, cancer is still among the dominant causes of death worldwide. One of the crucial challenges in the clinical management of cancer is primary (intrinsic) and secondary (acquired) resistance to both conventional and targeted chemotherapeutics. Multiple mechanisms have been identifiedthat underlie intrinsic and acquired chemoresistance: these include impaired drug uptake, increased drug efflux, deletion of receptors, altered drug metabolism, quantitative and qualitative alterations in drug targets, increased DNA damage repair and various mechanisms of anti-apoptosis.

Source: Drug Resistance Updates - August 22, 2015 Category: Drugs & Pharmacology Authors: Sophie Taylor, Enrico Pierluigi Spugnini, Yehuda G. Assaraf, Tommaso Azzarito, Cyril Rauch, Stefano Fais Source Type: research