ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response

Conclusions:
The erythropoietin-analogue ARA290 dose-dependently reduced allodynia coupled to suppression of the spinal microglia response, suggestive of a mechanistic link between ARA290-induced suppression of central inflammation and relief of neuropathic pain symptoms.

Source: Molecular Pain - February 16, 2014 Category: Molecular Biology Authors: Maarten SwartjesMonique van VelzenMarieke NiestersLeon AartsMichael BrinesAnn DunneAnthony CeramiAlbert Dahan Source Type: research