Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines

This study provides the first investigation of pyroglutamyl Aβ in comparison with total Aβ (as shown by Aβ8–17 immunoreactivity) in dogs of different breeds, sizes, and ages. Our results indicate that canine cognitive dysfunction syndrome is relatively common among aged canines, thereby emphasizing the relevance of such populations to translational Alzheimer disease research.
Source: Journal of Neuropathology and Experimental Neurology - Category: Neurology Tags: Original Articles Source Type: research