Physiologically Based Pharmacokinetics Model Predicts the Lack of Inhibition by Repaglinide on the Metabolism of Pioglitazone

ConclusionRepaglinide has no significant inhibitory effect on the metabolism of pioglitazone in vivo,which is inconsistent with the in vitro results. The lack of an inhibitory effect was partly due to extensive plasma protein binding and high in vivo clearance of repaglinide, for the concentration of repaglinide in vivo was far smaller than in vitro. This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fbdd.1987

Source: Biopharmaceutics and Drug Disposition - August 21, 2015 Category: Drugs & Pharmacology Authors: Qingqing Xiao, Liling Tang, Ruijuan Xu, Wei Qian, Jin Yang Tags: Original Paper Source Type: research