Assessing breast cancer cell lines as tumour models by comparison of mRNA expression profiles

Conclusions: This study demonstrates that many of the differences between breast cancer cell lines and tumours are due to the absence of stromal and immune components in vitro. Hence, extra precautions should be taken when modelling extracellular proteins in vitro. The specific differences discovered emphasize the importance of choosing an appropriate model for each research question.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research