Serum N-glycan analysis in breast cancer patients – relation to tumour biology and clinical outcome

Glycosylation and related processes play important roles in cancer development and progression, including metastasis. Several studies have shown that N-glycans have potential diagnostic value as cancer serum biomarkers. We have explored the significance of the abundance of particular serum N-glycan structures as important features of breast tumour biology by studying the serum glycome and tumour transcriptome (mRNA and miRNA) of 104 breast cancer patients. Integration of these types of molecular data allows us to study the relationship between serum glycans and transcripts representing functional pathways, such as metabolic pathways or DNA damage response.

Source: Molecular Oncology - August 18, 2015 Category: Cancer & Oncology Authors: Vilde D. Haakensen, Israel Steinfeld, Radka Saldova, Akram Asadi Shehni, Ilona Kifer, Bjørn Naume, Pauline M. Rudd, Anne-Lise Børresen-Dale, Zohar Yakhini Source Type: research