Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls

Conclusions:
Our findings support truncating variants in PALB2 as high-penetrance breast cancer susceptibility alleles, and suggest that a common missense variant may also lead to a low level of increased breast cancer risk.

Source: Breast Cancer Research - August 19, 2015 Category: Cancer & Oncology Authors: Ella ThompsonKylie GorringeSimone RowleyMichelle Wong-BrownSimone McInernyNa LiAlison TrainerLisa DevereuxMaria DoyleJason LiRichard LupatMartin DelatyckiGillian MitchellPaul JamesRodney ScottIan CampbellLifePool Investigators Source Type: research